Research ArticleMUCOSAL IMMUNOLOGY

Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity

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Science Immunology  20 Dec 2019:
Vol. 4, Issue 42, eaax1027
DOI: 10.1126/sciimmunol.aax1027

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Early-Life Licensing of Antiviral IgA Immunity

Mucosal immune responses after exposure to pathogens are influenced by multiple factors, including key developmental milestones achieved before birth or during the neonatal period. Li et al. investigated when during mouse immune system development signals initiated by lymphotoxin (LT) expression are needed to enable an effective mucosal IgA antibody response after rotavirus infection of adult mice. Transient interruption of signaling by the LT receptor during late embryonic life was sufficient to induce persistent defects in stromal cells resident in the mesenteric lymph node that impaired the IgA antirotavirus response of adult mice without interfering with IgA responses to commensal bacteria. These findings highlight the pivotal role early-life exposures play in configuring the mammalian immune system.

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