Research ArticleMUCOSAL IMMUNOLOGY
Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity
- View ORCID ProfileConglei Li1,
- Evelyn Lam1,
- Christian Perez-Shibayama2,
- Lesley A. Ward1,
- View ORCID ProfileJianbo Zhang3,
- View ORCID ProfileDennis Lee1,
- View ORCID ProfileAlbert Nguyen1,
- View ORCID ProfileMusaddeque Ahmed4,
- Emma Brownlie5,
- View ORCID ProfileKirill V. Korneev6,
- View ORCID ProfileOlga Rojas1,
- View ORCID ProfileTian Sun1,
- View ORCID ProfileWilliam Navarre5,
- View ORCID ProfileHousheng Hansen He4,
- View ORCID ProfileShan Liao3,
- View ORCID ProfileAlberto Martin1,
- View ORCID ProfileBurkhard Ludewig2 and
- View ORCID ProfileJennifer L. Gommerman1,*
- 1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
- 2Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
- 3Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
- 4Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada.
- 5Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
- 6Engelhardt Institute of Molecular Biology, Russian Academy of Sciences and Department of Immunology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.
- ↵*Corresponding author. Email: jen.gommerman{at}utoronto.ca
See allHide authors and affiliations
Science Immunology 20 Dec 2019:
Vol. 4, Issue 42, eaax1027
DOI: 10.1126/sciimmunol.aax1027
Vol. 4, Issue 42, eaax1027
DOI: 10.1126/sciimmunol.aax1027
Conglei Li
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Evelyn Lam
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Christian Perez-Shibayama
2Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Lesley A. Ward
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Jianbo Zhang
3Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dennis Lee
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Albert Nguyen
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Musaddeque Ahmed
4Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada.
Emma Brownlie
5Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Kirill V. Korneev
6Engelhardt Institute of Molecular Biology, Russian Academy of Sciences and Department of Immunology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.
Olga Rojas
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Tian Sun
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
William Navarre
5Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Housheng Hansen He
4Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada.
Shan Liao
3Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Alberto Martin
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Burkhard Ludewig
2Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Jennifer L. Gommerman
1Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
