Research ArticleALLERGY

Clec10a regulates mite-induced dermatitis

See allHide authors and affiliations

Science Immunology  06 Dec 2019:
Vol. 4, Issue 42, eaax6908
DOI: 10.1126/sciimmunol.aax6908

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Dermatitis details

House dust mite (HDM) is an allergen associated with a variety of diseases, including asthma and atopic dermatitis (AD). The NC/Nga mouse strain develops severe AD in response to HDM, and Kanemaru et al. have now identified a stop-gain mutation, the Clec10a C-type lectin receptor, that is associated with this response. HDM-induced dermatitis was driven by TLR4-mediated inflammatory responses, and asialoglycoprotein receptor 1 (Asgr1) functions as a Clec10a homolog in humans. They also identified a mucin-like molecule in HDM that can function as a ligand for Clec10a and Asgr1. These results provide insight into mechanisms associated with HDM-mediated dermatitis.

View Full Text

Stay Connected to Science Immunology