Research ArticleTUMOR IMMUNITY

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

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Science Immunology  13 Dec 2019:
Vol. 4, Issue 42, eaax8189
DOI: 10.1126/sciimmunol.aax8189

Article Information

vol. 4 no. 42

Published By: 
  • Received April 25, 2019
  • Accepted November 7, 2019
  • .

Author Information

  1. Marie Jo Halaby1,2,
  2. Kebria Hezaveh1,2,
  3. Sara Lamorte1,2,
  4. M. Teresa Ciudad1,2,
  5. Andreas Kloetgen3,
  6. Bethany L. MacLeod1,2,
  7. Mengdi Guo1,2,
  8. Ankur Chakravarthy4,
  9. Tiago Da Silva Medina5,
  10. Stefano Ugel6,
  11. Aristotelis Tsirigos3,7,8,
  12. Vincenzo Bronte6,
  13. David H. Munn9,10,
  14. Trevor J. Pugh1,4,11,
  15. Daniel D. De Carvalho1,4,
  16. Marcus O. Butler1,
  17. Pamela S. Ohashi1,2,4,
  18. David G. Brooks1,2 and
  19. Tracy L. McGaha1,2,*
  1. 1Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  2. 2Department of Immunology, University of Toronto, Toronto, ON, Canada.
  3. 3Department of Pathology, New York University School of Medicine, New York, NY, USA.
  4. 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  5. 5A.C. Camargo Cancer Center, Sao Paulo, Brazil.
  6. 6Department of Medicine, Immunology Section, Verona University Hospital, Verona, Italy.
  7. 7Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.
  8. 8Applied Bioinformatics Laboratories, New York University School of Medicine, New York, NY, USA.
  9. 9Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA.
  10. 10Georgia Cancer Center, Augusta, GA, USA.
  11. 11Ontario Institute for Cancer Research, Toronto, ON, Canada.
  1. *Corresponding author. Email: tmcgaha{at}


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