Contents
January 2020
Vol 5, Issue 43
Vol 5, Issue 43
Focus
- A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade
PD-1 mediates antitumor immunity by regulating lineage fate commitment and function of myeloid cells (see the related Research Article by Strauss et al.).
Research Articles
- Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer
EGFR inhibitor erlotinib synergizes with anti–PD-1 in a mouse model of lung adenocarcinoma.
- Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation
Prkd2-dependent phosphorylation of Bcl6 inhibits TFH cell differentiation.
- Human DNA-PK activates a STING-independent DNA sensing pathway
Burleigh et al. report a STING-independent DNA sensing pathway in human cells that relies on DNA-PK.
- Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
GSDME-mediated target cell pyroptosis by CAR T cells activates macrophages to release proinflammatory cytokines for CRS.
- Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2
Aeroallergens and ATP elicit cysteinyl leukotrienes from nasal brush cells through the purinergic receptor P2Y2.
- BATF acts as an essential regulator of IL-25–responsive migratory ILC2 cell fate and function
BATF-deficient mice lack iILC2 cells, which serve as an important early source of IL-4/IL-13 upon helminth infection.
- Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory
Long-lived IgE+ plasma cells in the bone marrow confer IgE memory and produce allergen-specific IgE that can drive anaphylaxis.
- Targeted deletion of PD-1 in myeloid cells induces antitumor immunity
PD-1 ablation regulates metabolism-driven lineage fate commitment of myeloid progenitors and differentiation of effector myeloid cells (see the related Focus by Rudd).
- Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products
CD1a, an abundant lipid antigen–presenting molecule in human skin, mediates T cell responses to small contact allergens.
Review
- Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity
Preserving a homeostatic balance with resident microbial communities of the oropharynx depends on a measured dose of type 17 immunity.
Editors' Choice
- Cis interactions make immune checkpoint blockade more trans-parent
PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.
- “B”-fing up immune-mediated diseases
Extensive characterization of B cell receptor repertoires across six immune-mediated diseases reveals novel insights into disease pathogenesis.
Technical Comment
- Technical comment on “Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis”
Reassessment of citrullinome cargo in neutrophil extracellular traps confirms the presence of citrullinated peptides.
Erratum
About The Cover
ONLINE COVER Turning Anti–PD-1 on Its Head. This month's cover illustration is a 3D rendition of pembrolizumab, one of several therapeutic monoclonal antibodies against human PD-1 being used for cancer immunotherapy. Based on results with a new conditional allele of the Pdcd1 gene in mice, Strauss et al. report that PD-1 expression on both myeloid and T cells is relevant to the immune stimulatory effects of anti–PD-1. A Focus commentary by Rudd discusses the findings of Strauss et al. The illustration was created with NGL Viewer using x-ray crystallography data deposited in the RCSB Protein Data Bank. [CREDIT: PDB 5DK3]
