January 2020
Vol 5, Issue 43

About The Cover

Cover image expansion

ONLINE COVER Turning Anti–PD-1 on Its Head. This month's cover illustration is a 3D rendition of pembrolizumab, one of several therapeutic monoclonal antibodies against human PD-1 being used for cancer immunotherapy. Based on results with a new conditional allele of the Pdcd1 gene in mice, Strauss et al. report that PD-1 expression on both myeloid and T cells is relevant to the immune stimulatory effects of anti–PD-1. A Focus commentary by Rudd discusses the findings of Strauss et al. The illustration was created with NGL Viewer using x-ray crystallography data deposited in the RCSB Protein Data Bank. [CREDIT: PDB 5DK3]