Research ArticleIMMUNOTHERAPY

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

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Science Immunology  17 Jan 2020:
Vol. 5, Issue 43, eaax7969
DOI: 10.1126/sciimmunol.aax7969

Article Information

vol. 5 no. 43

PubMed: 
Published By: 
History: 
  • Received April 23, 2019
  • Revision received August 28, 2019
  • Accepted December 19, 2019
  • .

Author Information

  1. Yuying Liu1,2,*,
  2. Yiliang Fang1,*,
  3. Xinfeng Chen3,*,
  4. Zhenfeng Wang1,
  5. Xiaoyu Liang1,
  6. Tianzhen Zhang1,
  7. Mengyu Liu1,
  8. Nannan Zhou1,
  9. Jiadi Lv1,
  10. Ke Tang4,
  11. Jing Xie1,
  12. Yunfeng Gao1,
  13. Feiran Cheng1,
  14. Yabo Zhou1,
  15. Zhen Zhang3,
  16. Yu Hu5,
  17. Xiaohui Zhang6,
  18. Quanli Gao7,
  19. Yi Zhang3 and
  20. Bo Huang1,2,4,
  1. 1Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing 100005, China.
  2. 2Clinical Immunology Center, CAMS, Beijing 100005, China.
  3. 3Biotherapy Center and Cancer Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
  4. 4Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  5. 5Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  6. 6Peking University People’s Hospital, Peking University Institute of Hematology, Beijing 100044, China.
  7. 7Department of Immunology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan 450008, China.
  1. Corresponding author. Email: tjhuangbo{at}hotmail.com
  • * These authors contributed equally to this work.

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