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Cis interactions make immune checkpoint blockade more trans-parent

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Science Immunology  03 Jan 2020:
Vol. 5, Issue 43, eaba7107
DOI: 10.1126/sciimmunol.aba7107

Abstract

PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

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