Contents
February 2020
Vol 5, Issue 44
Vol 5, Issue 44
Research Articles
- PAX1 is essential for development and function of the human thymus
PAX1 deficiency causes a syndromic form of SCID by altering differentiation of thymic epithelial cells and other pharyngeal pouch tissues.
- A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis
The type 2 IL-4 receptor has a key role in atopic dermatitis and is therefore a potential therapeutic target.
- Increased islet antigen–specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes–protective haplotype
The DR1501-DQ6 haplotype confers protection against type 1 diabetes through islet-specific Tregs and IL-10–producing Teffs.
- Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution
Mucosal immunoglobulins of primitive and modern vertebrates evolved to control pathogens and preserve microbiota homeostasis.
- Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination
A noncoding RNA–expressing element drives IgA class switch recombination.
Report
- Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes
CSiN score is an improved tool to assess the overall quality of tumor neoantigens that predicts response to immunotherapy.
Research Resource
- Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics
Alshetaiwi et al. identify CD84 to be a robust MSDC-specific cell surface marker in breast cancers.
Editors' Choice
- Winning with the B team?
The accumulation of B cells and tertiary lymphoid organs in metastatic melanoma patients receiving checkpoint blockade therapy was associated with long-term survival.
- Kill shot: Flu vaccine is a stone cold cancer killer
Injection of seasonal influenza vaccine into tumors enhances local and systemic anti-cancer immunity and sensitizes previously resistant tumors to immune checkpoint therapy.
About The Cover
ONLINE COVER Mucosal IgT Earns Its Stripes. This month's cover features a pair of rainbow trout (Oncorhynchus mykiss) out for a swim. Immunoglobulin T (IgT) is the specialized mucosal antibody of teleost fish, including trout. In this issue, Xu et al. report that temporary depletion of trout IgT led to dysbiosis of the gill bacterial community and increased susceptibility to infection by a mucosal parasite. [CREDIT: TIM FITZHARRIS/MINDEN PICTURES]
