Research ArticleALLERGY

A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis

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Science Immunology  14 Feb 2020:
Vol. 5, Issue 44, eaaw2938
DOI: 10.1126/sciimmunol.aaw2938

Dermatitis details

Type 2 inflammation mediated by IL-4 and IL-13 has key roles in atopic dermatitis (AD). IL-4 and IL-13 signal via the type 2 IL-4 receptor (R), but the contribution of this receptor to AD is not well understood. Bitton et al. now show that dermatitis symptoms and expression of TNF-α, CXCL1, and CCL11 were dependent on IL-13 signaling via the type 2 IL-4R in nonhematopoietic cells, and these responses could be inhibited by pharmacological blockade of IL-13Rα1. In contrast, IL-4 signaling via the type 1 IL-4R was required for IL-4 and CCL24 expression and eosinophilia. These results provide insight into the role of type 2 IL-4R in AD and how it may be potentially targeted for other allergic diseases.

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