Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution

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Science Immunology  07 Feb 2020:
Vol. 5, Issue 44, eaay3254
DOI: 10.1126/sciimmunol.aay3254

Article Information

vol. 5 no. 44

Published By: 
  • Received July 17, 2019
  • Accepted January 16, 2020
  • .

Author Information

  1. Zhen Xu1,2,*,
  2. Fumio Takizawa1,3,*,
  3. Elisa Casadei4,
  4. Yasuhiro Shibasaki1,
  5. Yang Ding1,
  6. Thomas J. C. Sauters4,
  7. Yongyao Yu1,
  8. Irene Salinas4, and
  9. J. Oriol Sunyer1,
  1. 1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
  3. 3Faculty of Marine Science and Technology, Fukui Prefectural University, Obama, Fukui 917-0003, Japan.
  4. 4Center for Evolutionary and Theoretical Immunology (CETI), Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
  1. Corresponding author. Email: sunyer{at} (J.O.S.); isalinas{at} (I.S.)
  • * These authors contributed equally to this work.


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