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Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination

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Science Immunology  07 Feb 2020:
Vol. 5, Issue 44, eaay5864
DOI: 10.1126/sciimmunol.aay5864

Article Information

vol. 5 no. 44

Published By: 
  • Received July 1, 2019
  • Accepted January 9, 2020
  • .

Author Information

  1. Gerson Rothschild1,*,
  2. Wanwei Zhang1,*,
  3. Junghyun Lim1,*,
  4. Pankaj Kumar Giri1,,
  5. Brice Laffleur1,
  6. Yiyun Chen2,
  7. Mingyan Fang3,4,
  8. Yuling Chen5,
  9. Lekha Nair1,
  10. Zhi-Ping Liu6,
  11. Haiteng Deng5,
  12. Lennart Hammarström3,4,
  13. Jiguang Wang2 and
  14. Uttiya Basu1,
  1. 1Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  2. 2Division of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong SAR, China.
  3. 3BGI-Shenzhen, Shenzhen 518083, China.
  4. 4Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.
  5. 5School of Life Sciences, Tsinghua University, Beijing 100084, China.
  6. 6Department of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, Shandong 250061, China.
  1. Corresponding author. Email: ub2121{at}
  • * These authors contributed equally to this work.

  • Present address: Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.


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