Research ResourcesTUMOR IMMUNOLOGY

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

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Science Immunology  21 Feb 2020:
Vol. 5, Issue 44, eaay6017
DOI: 10.1126/sciimmunol.aay6017

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Getting a hold on MDSCs

How myeloid-derived suppressor cells (MDSCs) arise and whether they can be therapeutically targeted akin to exhausted T cells are both areas of active investigation. A persistent challenge in studying MDSCs has been the identification of MDSC-specific cell surface markers that can facilitate their isolation and characterization. Here, by carrying out scRNAseq in a mouse model of breast cancer, Alshetaiwi et al. have defined gene signatures that distinguish MDSCs from other myeloid and granulocytic cells. By mining these datasets, they have identified CD84 to be a robust cell surface marker for identification of MDSCs in both human and murine breast cancer. Whether their findings can be extended to MDSCs in other cancer settings remains to be seen.

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