Research ArticleLYMPHATICS

Lymph node stromal CCL2 limits antibody responses

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Science Immunology  20 Mar 2020:
Vol. 5, Issue 45, eaaw0693
DOI: 10.1126/sciimmunol.aaw0693

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Sending messages to plasma cells

Lymph node stromal cells serve as a platform that facilitates functional interactions between distinct immune cell types. Here, Dasoveanu et al. have examined the role of fibroblastic reticular cells (FRCs), a type of lymph node stromal cells, in regulating the survival of antibody-producing plasma cells. They report FRCs to be a critical source of chemokine ligand 2 (CCL2), and that CCL2 produced by FRCs tempers the expansion of plasma cells. Plasma cells do not express the CCL2 receptor CCR2; rather, CCR2-expressing monocytes respond to CCL2 by generating molecules that relay signals from the FRCs to the plasma cells. The study adds to the growing appreciation of the roles of lymph node stromal cells in fine-tuning adaptive immune responses.

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