Research ArticleALLERGY

Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy

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Science Immunology  06 Mar 2020:
Vol. 5, Issue 45, eaay4209
DOI: 10.1126/sciimmunol.aay4209

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Peanuts in the gut

Peanut allergy affects millions of children and adults worldwide, and peripheral blood IgE+ B cells have been studied in previous peanut allergy studies. Less is known about B cells in tissues exposed to peanuts, and Hoh et al. have now characterized IgE+ B cell clones in the blood, esophagus, stomach, and duodenum in 19 peanut-allergic patients. The stomach and duodenum were enriched for IgE+ B cells with a plasma cell phenotype in allergic patients. High-throughput DNA analysis indicated that tissues were the sites of local isotype switching, and similar antibody sequences for the Ara h 2 peanut allergen were shared between patients. These data better define a role for IgE+ B cells in the gastrointestinal tract in peanut allergy.

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