Contents
May 2020
Vol 5, Issue 47
Vol 5, Issue 47
Focus
- Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward
Defining acceptable performance characteristics for SARS-CoV-2 serological tests requires factoring in how the results will be used.
- HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19
JAK kinase inhibitors are being investigated as a way of managing cytokine storm in patients with severe COVID-19.
Research Articles
- TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
The SARS-CoV-2 virus infects cultured ACE2-expressing human enterocytes aided by the TMPRSS2 and TMPRSS4 serine proteases.
- IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation
The transcription factor IRF5 promotes macrophage differentiation in Helicobacter-driven intestinal inflammation in mice.
- Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization
Generation of peanut-specific gut immunoglobulin A antibodies is independent of T follicular helper cells.
- A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain
A glycan-modified RSV nanoparticle vaccine displaying multimeric pre-F protein focuses antibody responses on neutralizing epitopes.
Research Resource
- Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing
Heterogeneity of small intestine intraepithelial CD8+ T cells suggests functionally distinct subsets of TRM cells and their precursors.
Review
- Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair
This Review summarizes the recent advances in our understanding of the roles of regulatory T cells in skin injury and tissue repair.
Editors' Choice
- Sestrins teach old T cells new tricks
Sestrin proteins dampen TCR signaling and induce antigen-independent natural killer-like cytotoxicity in highly differentiated CD8 T cells.
About The Cover
ONLINE COVER Sugarcoated Vaccine. This month's cover illustration depicts the trimeric pre-fusion (pre-F) protein of respiratory syncytial virus (RSV) found in an engineered nanoparticle vaccine construct. Swanson et al. describe the synthesis and preclinical testing of an RSV vaccine candidate consisting of eight of these pre-F spikes attached to a ferritin core. The magenta-colored branched glycans engineered onto the protein surface shield poorly neutralizing epitopes on pre-F, allowing antibody responses to focus instead on the known neutralizing epitopes indicated by red patches. [CREDIT: K. SWANSON ET AL./SCIENCE IMMUNOLOGY]
