Research ArticleFOOD ALLERGY

Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization

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Science Immunology  08 May 2020:
Vol. 5, Issue 47, eaay2754
DOI: 10.1126/sciimmunol.aay2754

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Modeling peanut allergy in mice

One of the challenges of understanding food allergies is developing animal models that mirror human food allergies. Here, Zhang et al. have developed a peanut allergy model in mice where feeding mice peanuts alongside immune adjuvant, cholera toxin, promoted the development of peanut-specific antibodies. In addition to peanut-reactive immunoglobulin A (IgA) antibodies, these mice also developed peanut-specific IgE and IgG antibodies. Although development of IgA was independent of T follicular helper (Tfh) cells, Tfh cells were required for the generation of peanut-specific IgE and IgG antibodies. In addition to developing a model to study peanut allergy in mice, their results have also brought to the fore the role of Tfh cells in driving distinct antibody-mediated responses.

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