Research ResourcesT CELL MEMORY

Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

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Science Immunology  15 May 2020:
Vol. 5, Issue 47, eaaz6894
DOI: 10.1126/sciimmunol.aaz6894

Stepping down resident memory lane

The antigen-specific CD8+ T response to microbial infection includes the differentiation of a subset of CD8+ T cells into tissue-resident memory (TRM) cells that stop circulating and become confined within a nonlymphoid tissue. Kurd et al. used single-cell RNA sequencing of mouse CD8+ T cells at multiple time points during the first 90 days after viral infection to characterize how this differentiation process unfolds in the small intestine and tracks the emergence of heterogeneity among TRM cells. They found evidence for TRM cell precursors in the intestine by 4 days after infection and identified several putative regulators of TRM cell differentiation. The results of this study provide a valuable transcriptomic atlas that will facilitate further investigation into immune functions provided by TRM cells.

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