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TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

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Science Immunology  13 May 2020:
Vol. 5, Issue 47, eabc3582
DOI: 10.1126/sciimmunol.abc3582

Article Information

vol. 5 no. 47

PubMed: 
Published By: 
History: 
  • Received April 20, 2020
  • Accepted May 8, 2020
  • .

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Author Information

  1. Ruochen Zang1,2,*,
  2. Maria Florencia Gomez Castro1,*,
  3. Broc T. McCune3,
  4. Qiru Zeng1,
  5. Paul W. Rothlauf1,4,
  6. Naomi M. Sonnek5,
  7. Zhuoming Liu1,
  8. Kevin F. Brulois6,7,
  9. Xin Wang2,
  10. Harry B. Greenberg7,8,
  11. Michael S. Diamond1,3,9,
  12. Matthew A. Ciorba5,
  13. Sean P. J. Whelan1 and
  14. Siyuan Ding1,
  1. 1Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  2. 2Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao, China.
  3. 3Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  4. 4Program in Virology, Harvard Medical School, 200 Longwood Ave., Boston, MA, USA.
  5. 5Division of Gastroenterology, Department of Medicine, Washington School of Medicine, St. Louis, MO, USA.
  6. 6Department of Pathology, Stanford School of Medicine, Stanford, CA, USA.
  7. 7VA Palo Alto Health Care System, Department of Veterans Affairs, Palo Alto, CA, USA.
  8. 8Division of Gastroenterology and Hepatology, Department of Medicine, and Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, CA, USA.
  9. 9Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  1. Corresponding author. Email: siyuan.ding{at}wustl.edu
  • * These authors contributed equally to this work.

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