June 2020
Vol 5, Issue 48

About The Cover

Cover image expansion

ONLINE COVER Lighting Up a Viral On-Ramp. This month's cover shows a coronal section through a virally infected mouse nasal mucosa and olfactory bulbs. Vesicular stomatitis virus (VSV, green) can be observed in olfactory sensory neurons (OSNs, red) that line olfactory turbinates in the nose one day after nasal infection. Viruses like VSV that enter the upper airway can sometimes infect OSNs and spread to the olfactory bulbs in the brain via projecting axon fibers. Moseman et al. used a Cre-recombinase expressing VSV and intravital imaging to show that once virus reaches the brain, microglia play an important role in antiviral defense by acquiring viral antigen from infected neurons and cross-presenting it to CD8+ T cells responsible for noncytolytic virus clearance from neurons. [CREDIT: A. MOSEMAN ET AL./SCIENCE IMMUNOLOGY]