Research ArticleALLERGY

Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma

See allHide authors and affiliations

Science Immunology  12 Jun 2020:
Vol. 5, Issue 48, eaba6087
DOI: 10.1126/sciimmunol.aba6087

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Finding a TRAIL to allergy control

House dust mites (HDMs) are a major source of aeroallergens that trigger human allergic responses including asthma. To characterize the heterogeneity of human CD4+ T helper (TH) cell responses to HDM antigens, Seumois et al. stimulated blood T cells with HDM peptides and isolated the freshly activated T cells for single-cell RNA sequencing. A TH subset expressing an interferon response gene signature (designated THIFNR) and the cell death–inducing TRAIL ligand was more frequent in individuals without HDM allergy. This TRAIL+ THIFNR subset may function to restrain allergic TH2 responses. Individuals with both HDM allergy and asthma were enriched for interleukin-9–producing TH2 cells. These findings provide a basis for designing more precise approaches to thwart pathogenic TH responses contributing to allergic asthma.

View Full Text

Stay Connected to Science Immunology