Research ArticleHIV

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates

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Science Immunology  19 Jun 2020:
Vol. 5, Issue 48, eabb1025
DOI: 10.1126/sciimmunol.abb1025

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Live long and protect

While vaccines elicit robust short-term responses, maintaining sustained and durable antibody responses to vaccines remains a challenge. Durability of antibody responses not only depends on the antigen but also on the adjuvants used in the vaccine. Here, Kasturi et al. have used a nanoparticle and a clinically applicable alum adsorbed formulation of 3M-052, a TLR7/8 agonist to promote sustained antibody responses to an HIV-1 envelope (Env) protein vaccine in rhesus macaques. They report that 3M-052–adjuvanted Env vaccination led to the development of durable antibody responses that were readily detectable a year after immunization, and they attribute this to the ability of 3M-052 to prime and sustain long-lived plasma cell responses. 3M-052 now joins an elite set of adjuvants that could help shape vaccination in the 21st century.

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