Research ArticleHIV

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates

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Science Immunology  19 Jun 2020:
Vol. 5, Issue 48, eabb1025
DOI: 10.1126/sciimmunol.abb1025

Article Information

vol. 5 no. 48

PubMed: 
Published By: 
History: 
  • Received January 30, 2020
  • Accepted May 22, 2020
  • .

Author Information

  1. Sudhir Pai Kasturi1,*,
  2. Mohammed Ata Ur Rasheed1,2,*,
  3. Colin Havenar-Daughton3,
  4. Mathew Pham1,
  5. Traci Legere1,
  6. Zarpheen Jinnah Sher1,
  7. Yevgeny Kovalenkov1,
  8. Sanjeev Gumber1,
  9. Jessica Y. Huang1,
  10. Raphael Gottardo4,
  11. William Fulp4,
  12. Alicia Sato4,
  13. Sheetal Sawant5,6,
  14. Sherry Stanfield-Oakley5,
  15. Nicole Yates5,6,
  16. Celia LaBranche5,
  17. S. Munir Alam5,
  18. Georgia Tomaras5,6,
  19. Guido Ferrari5,6,
  20. David Montefiori5,
  21. Jens Wrammert1,
  22. Francois Villinger1,7,
  23. Mark Tomai8,
  24. John Vasilakos8,
  25. Christopher B. Fox9,10,
  26. Steven G. Reed9,11,
  27. Barton F. Haynes5,
  28. Shane Crotty3,12,
  29. Rafi Ahmed1,2, and
  30. Bali Pulendran1,13,
  1. 1Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.
  2. 2Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA.
  3. 3Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA.
  4. 4Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  5. 5Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.
  6. 6Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA.
  7. 7New Iberia Research Center, University of Louisiana Lafayette, New Iberia, LA, USA.
  8. 83M Drug Delivery Systems, St. Paul, MN, USA.
  9. 9Infectious Disease Research Institute, Seattle, WA, USA.
  10. 10Department of Global Health, University of Washington, Seattle, WA, USA.
  11. 11HDT Bio, Seattle, WA, USA.
  12. 12Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA, USA.
  13. 13Departments of Pathology and Microbiology & Immunology, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  1. Corresponding author. Email: bpulend{at}stanford.edu (B.P.); rahmed{at}emory.edu (R.A.)
  • * These authors contributed equally to this work.

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