Research ArticleNEUROIMMUNOLOGY

T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection

See allHide authors and affiliations

Science Immunology  05 Jun 2020:
Vol. 5, Issue 48, eabb1817
DOI: 10.1126/sciimmunol.abb1817

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Safeguarding the sense of smell

Given the proximity of the olfactory bulb to the upper airways, it is surprising that viruses that infect the upper airways, including influenza, rarely infect the brain. In mice, intranasal infection with vesicular stomatitis virus (VSV) does result in infection of sensory neurons in the olfactory bulb. Using VSV that expresses a fluorescent reporter, Moseman et al. examined the ability of VSV to infect distinct cell types within olfactory bulb. Although VSV infection was restricted to neurons within the olfactory bulb, they found that microglial cells that were not infected by VSV to be the key in priming T cell responses that promoted viral clearance.

View Full Text

Stay Connected to Science Immunology