Research ArticleMACROPHAGES

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

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Science Immunology  19 Jun 2020:
Vol. 5, Issue 48, eabc4466
DOI: 10.1126/sciimmunol.abc4466

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Sex, age, and the macrophage

Peritoneal macrophages are known to contribute to the pathology of peritonitis, endometriosis, and cancer, but the effects of age and sex on the biology of these cells are not well understood. Here, Bain et al. show that replenishment of peritoneal macrophages from the bone marrow is much higher in males compared with females. This results in marked sexual dimorphisms in the phenotypic identity of peritoneal macrophages between the sexes, including differential CD209b expression. Age- and sex-associated differences in macrophage turnover also affect resistance to pneumococcal peritonitis. These findings provide insight into the effects of sex and age on peritoneal inflammation and infection.

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