July 2020
Vol 5, Issue 49

About The Cover

Cover image expansion

ONLINE COVER Frozen Footprints of Antibody Fabs. This month's cover features a 3D reconstruction of the capsid surface of human enterovirus D68 (EV-D68), a virus linked to an emerging polio-like illness called acute flaccid myelitis (AFM). The blue and gold patches represent the distinct binding sites on the icosahedral capsid (colored in cyan) occupied by two neutralizing human monoclonal antibodies to EV-D68 identified by Vogt et al. The image was generated by cryo–electron microscopy of immune complexes formed by mixing virions with a 200-fold molar excess of antibody Fab fragments. The antibody depicted in blue is a potential therapeutic agent in human AFM based on its broad reactivity with EV-D68 clades and its ability to protect mice in a model of EV-D68–induced neurologic disease. [CREDIT: KARA JIANING FU/PURDUE UNIVERSITY]