Gut T cell–independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells

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Science Immunology  31 Jul 2020:
Vol. 5, Issue 49, eaat7117
DOI: 10.1126/sciimmunol.aat7117

Article Information

vol. 5 no. 49

Published By: 
  • Received March 27, 2018
  • Accepted July 9, 2020
  • .

Author Information

  1. E. K. Grasset1,2,*,,
  2. A. Chorny1,*,
  3. S. Casas-Recasens1,*,
  4. C. Gutzeit1,
  5. G. Bongers,
  6. I. Thomsen4,
  7. L. Chen1,
  8. Z. He1,
  9. D. B. Matthews1,
  10. M. A. Oropallo1,
  11. P. Veeramreddy1,
  12. M. Uzzan1,
  13. A. Mortha5,
  14. J. Carrillo1,6,
  15. B. S. Reis7,
  16. M. Ramanujam8,
  17. J. Sintes9,
  18. G. Magri9,
  19. P. J. Maglione1,
  20. C. Cunningham-Rundles1,
  21. R. J. Bram10,
  22. J. Faith1,
  23. S. Mehandru1,
  24. O. Pabst4 and
  25. A. Cerutti1,9,11,
  1. 1Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  2. 2Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 77 Stockholm, Sweden.
  3. 3Department of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  4. 4Institute of Molecular Medicine, Aachen University, Aachen D-52074, Germany.
  5. 5Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  6. 6IrsiCaixa, Hospital Germans Trias i Pujol, Badalona 08916, Spain.
  7. 7Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  8. 8Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877, USA.
  9. 9Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona 08003, Spain.
  10. 10Departments of Pediatrics and Immunology, Mayo Clinic, Rochester, MN 55905, USA.
  11. 11Catalan Institute for Research and Advanced Studies (ICREA), Barcelona 08003, Spain.
  1. Corresponding author. Email: emilie.grasset{at} (E.K.G.); acerutti{at} (A. Cerutti)
  • * These authors contributed equally to this work.


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