Research ArticleINFECTIOUS DISEASES

Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

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Science Immunology  03 Jul 2020:
Vol. 5, Issue 49, eaba4902
DOI: 10.1126/sciimmunol.aba4902

Article Information

vol. 5 no. 49

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History: 
  • Received December 8, 2019
  • Accepted June 12, 2020
  • .

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Author Information

  1. Matthew R. Vogt1,*,
  2. Jianing Fu2,*,
  3. Nurgun Kose3,
  4. Lauren E. Williamson4,
  5. Robin Bombardi3,
  6. Ian Setliff5,
  7. Ivelin S. Georgiev3,4,
  8. Thomas Klose2,
  9. Michael G. Rossmann2,,
  10. Brett L. Hurst6,
  11. E. Bart Tarbet6,
  12. Yury A. Bochkov7,
  13. James E. Gern7,8,
  14. Richard J. Kuhn2 and
  15. James E. Crowe Jr.1,3,4,5,
  1. 1Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA.
  2. 2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
  3. 3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
  4. 4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  5. 5Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.
  6. 6Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
  7. 7Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
  8. 8Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  1. Corresponding author. Email: james.crowe{at}vumc.org
  • * These authors contributed equally to this work.

  • Deceased.

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