Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

Matthew R. Vogt; Jianing Fu; Nurgun Kose; Lauren E. Williamson; Robin Bombardi; Ian Setliff; Ivelin S. Georgiev; Thomas Klose; Michael G. Rossmann; Yury A. Bochkov; James E. Gern; Richard J. Kuhn; James E. Crowe

doi:10.1126/sciimmunol.aba4902

Research ArticleINFECTIOUS DISEASES

Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

View ORCID ProfileMatthew R. Vogt ¹,*,
View ORCID ProfileJianing Fu²,*,
Nurgun Kose³,
View ORCID ProfileLauren E. Williamson⁴,
View ORCID ProfileRobin Bombardi³,
Ian Setliff⁵,
Ivelin S. Georgiev³,⁴,
View ORCID ProfileThomas Klose²,
Michael G. Rossmann²,†,
View ORCID ProfileYury A. Bochkov⁶,
James E. Gern ⁶,⁷,
View ORCID ProfileRichard J. Kuhn ² and
James E. Crowe Jr.¹,³,⁴,⁵,‡

¹Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA.
²Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
³Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁵Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.
⁶Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
⁷Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

↵‡Corresponding author. Email: james.crowe{at}vumc.org

↵* These authors contributed equally to this work.
↵† Deceased.

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Science Immunology 03 Jul 2020:
Vol. 5, Issue 49, eaba4902
DOI: 10.1126/sciimmunol.aba4902

Matthew R. Vogt

1Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA.

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Jianing Fu

2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.

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Nurgun Kose

3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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Lauren E. Williamson

4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

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Robin Bombardi

3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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Ian Setliff

5Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.

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Ivelin S. Georgiev

3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

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Thomas Klose

2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.

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Michael G. Rossmann

2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.

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Yury A. Bochkov

6Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.

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James E. Gern

6Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.

7Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

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Richard J. Kuhn

2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.

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James E. Crowe Jr.

1Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA.

3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

5Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.

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For correspondence: james.crowe@vumc.org

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Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

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