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Research ArticleINFECTIOUS DISEASES
Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease
- View ORCID ProfileMatthew R. Vogt1,*,
- View ORCID ProfileJianing Fu2,*,
- Nurgun Kose3,
- View ORCID ProfileLauren E. Williamson4,
- View ORCID ProfileRobin Bombardi3,
- Ian Setliff5,
- Ivelin S. Georgiev3,4,
- View ORCID ProfileThomas Klose2,
- Michael G. Rossmann2,†,
- View ORCID ProfileBrett L. Hurst6,
- View ORCID ProfileE. Bart Tarbet6,
- View ORCID ProfileYury A. Bochkov7,
- James E. Gern7,8,
- View ORCID ProfileRichard J. Kuhn2 and
- James E. Crowe Jr.1,3,4,5,‡
- 1Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA.
- 2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
- 3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
- 4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 5Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.
- 6Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
- 7Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
- 8Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
- ↵‡Corresponding author. Email: james.crowe{at}vumc.org
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Science Immunology 03 Jul 2020:
Vol. 5, Issue 49, eaba4902
DOI: 10.1126/sciimmunol.aba4902
Vol. 5, Issue 49, eaba4902
DOI: 10.1126/sciimmunol.aba4902
Matthew R. Vogt
1Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA.
Jianing Fu
2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Nurgun Kose
3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Lauren E. Williamson
4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Robin Bombardi
3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Ian Setliff
5Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.
Ivelin S. Georgiev
3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Thomas Klose
2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Michael G. Rossmann
2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Brett L. Hurst
6Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
E. Bart Tarbet
6Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Yury A. Bochkov
7Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
James E. Gern
7Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
8Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Richard J. Kuhn
2Department of Biological Sciences and Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
James E. Crowe Jr.
1Department of Pediatrics (Infectious Diseases), Vanderbilt University Medical Center, Nashville, TN, USA.
3Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
4Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
5Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.
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