Research ArticleT CELLS

TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells

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Science Immunology  03 Jul 2020:
Vol. 5, Issue 49, eaba7918
DOI: 10.1126/sciimmunol.aba7918

Article Information

vol. 5 no. 49

PubMed: 
Published By: 
History: 
  • Received January 8, 2020
  • Accepted May 22, 2020
  • .

Author Information

  1. Takuya Sekine1,*,
  2. André Perez-Potti1,*,
  3. Son Nguyen2,3,*,
  4. Jean-Baptiste Gorin1,
  5. Vincent H. Wu2,3,
  6. Emma Gostick4,
  7. Sian Llewellyn-Lacey4,
  8. Quirin Hammer1,
  9. Sara Falck-Jones5,
  10. Sindhu Vangeti5,
  11. Meng Yu5,
  12. Anna Smed-Sörensen5,
  13. Ahmed Gaballa6,
  14. Michael Uhlin7,8,
  15. Johan K. Sandberg1,
  16. Christian Brander9,10,11,
  17. Piotr Nowak12,
  18. Paul A. Goepfert13,
  19. David A. Price4,14,
  20. Michael R. Betts2,3 and
  21. Marcus Buggert1,
  1. 1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  2. 2Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  3. 3Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  4. 4Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  5. 5Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  6. 6Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  7. 7Department of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden.
  8. 8Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
  9. 9IrsiCaixa AIDS Research Institute, Badalona, Spain.
  10. 10Universitat de Vic–Universitat Central de Catalunya, Vic, Spain.
  11. 11Institució Catalana de Recerca i Estudis Avançats, ICREA, Barcelona, Spain.
  12. 12Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
  13. 13Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  14. 14Systems Immunity Research Institute, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  1. Corresponding author. Email: marcus.buggert{at}ki.se
  • * These authors contributed equally to this work.

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