Research ArticleTUMOR IMMUNOLOGY

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

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Science Immunology  17 Jul 2020:
Vol. 5, Issue 49, eabc2728
DOI: 10.1126/sciimmunol.abc2728

Article Information

vol. 5 no. 49

PubMed: 
Published By: 
History: 
  • Received April 15, 2020
  • Accepted June 4, 2020
  • .

Author Information

  1. Lawrence P. Andrews1,2,3,
  2. Ashwin Somasundaram1,2,3,4,
  3. Jessica M. Moskovitz1,2,3,
  4. Andrea L. Szymczak-Workman1,
  5. Chang Liu1,2,3,
  6. Anthony R. Cillo1,2,3,
  7. Huang Lin5,
  8. Daniel P. Normolle5,
  9. Kelly D. Moynihan6,7,
  10. Ichiro Taniuchi8,
  11. Darrell J. Irvine6,7,9,
  12. John M. Kirkwood3,4,
  13. Evan J. Lipson10,
  14. Robert L. Ferris2,3,11,
  15. Tullia C. Bruno1,2,3,
  16. Creg J. Workman1,2,3 and
  17. Dario A. A. Vignali1,2,3,*
  1. 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  2. 2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
  3. 3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
  4. 4Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  5. 5Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
  6. 6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  7. 7Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  8. 8RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.
  9. 9Howard Hughes Medical Institute, Chevy Chase, MD, USA.
  10. 10Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  11. 11Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  1. *Corresponding author. Email: dvignali{at}pitt.edu

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