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Research ArticleTUMOR IMMUNOLOGY
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding
- View ORCID ProfileLawrence P. Andrews1,2,3,
- View ORCID ProfileAshwin Somasundaram1,2,3,4,
- View ORCID ProfileJessica M. Moskovitz1,2,3,
- View ORCID ProfileAndrea L. Szymczak-Workman1,
- View ORCID ProfileChang Liu1,2,3,
- View ORCID ProfileAnthony R. Cillo1,2,3,
- View ORCID ProfileHuang Lin5,
- View ORCID ProfileDaniel P. Normolle5,
- View ORCID ProfileKelly D. Moynihan6,7,
- View ORCID ProfileIchiro Taniuchi8,
- View ORCID ProfileDarrell J. Irvine6,7,9,
- View ORCID ProfileJohn M. Kirkwood3,4,
- View ORCID ProfileEvan J. Lipson10,
- Robert L. Ferris2,3,11,
- Tullia C. Bruno1,2,3,
- View ORCID ProfileCreg J. Workman1,2,3 and
- View ORCID ProfileDario A. A. Vignali1,2,3,*
- 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
- 2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
- 3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
- 4Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
- 5Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
- 6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
- 7Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
- 8RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.
- 9Howard Hughes Medical Institute, Chevy Chase, MD, USA.
- 10Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- 11Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
- ↵*Corresponding author. Email: dvignali{at}pitt.edu
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Science Immunology 17 Jul 2020:
Vol. 5, Issue 49, eabc2728
DOI: 10.1126/sciimmunol.abc2728
Vol. 5, Issue 49, eabc2728
DOI: 10.1126/sciimmunol.abc2728
Lawrence P. Andrews
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Ashwin Somasundaram
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
4Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jessica M. Moskovitz
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Andrea L. Szymczak-Workman
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Chang Liu
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Anthony R. Cillo
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Huang Lin
5Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
Daniel P. Normolle
5Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
Kelly D. Moynihan
6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
7Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ichiro Taniuchi
8RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.
Darrell J. Irvine
6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
7Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
9Howard Hughes Medical Institute, Chevy Chase, MD, USA.
John M. Kirkwood
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
4Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Evan J. Lipson
10Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert L. Ferris
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
11Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Tullia C. Bruno
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Creg J. Workman
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Dario A. A. Vignali
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
3Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
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