Research ArticleIMMUNODEFICIENCY

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

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Science Immunology  10 Jul 2020:
Vol. 5, Issue 49, eabc3979
DOI: 10.1126/sciimmunol.abc3979

Article Information

vol. 5 no. 49

PubMed: 
Published By: 
History: 
  • Received April 23, 2020
  • Accepted June 4, 2020
  • .

Author Information

  1. Elisabeth Salzer1,2,3,4,*,
  2. Samaneh Zoghi1,2,3,5,6,*,
  3. Máté G. Kiss3,7,,
  4. Frieda Kage8,9,,
  5. Christina Rashkova1,3,10,,
  6. Stephanie Stahnke9,,
  7. Matthias Haimel1,2,3,,
  8. René Platzer11,
  9. Michael Caldera3,
  10. Rico Chandra Ardy1,2,3,
  11. Birgit Hoeger1,2,3,
  12. Jana Block1,2,3,
  13. David Medgyesi1,
  14. Celine Sin3,
  15. Sepideh Shahkarami5,12,13,
  16. Renate Kain14,
  17. Vahid Ziaee15,16,
  18. Peter Hammerl17,,
  19. Christoph Bock1,3,
  20. Jörg Menche3,
  21. Loïc Dupré1,18,
  22. Johannes B. Huppa11,
  23. Michael Sixt19,
  24. Alexis Lomakin1,2,3,
  25. Klemens Rottner8,9,
  26. Christoph J. Binder3,7,
  27. Theresia E. B. Stradal9,
  28. Nima Rezaei5,6,20 and
  29. Kaan Boztug2,1,3,4,10,§
  1. 1Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
  2. 2St. Anna Children’s Cancer Research Institute (CCRI), Vienna, Austria.
  3. 3CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  4. 4St. Anna Children’s Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  5. 5Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  6. 6Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  7. 7Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  8. 8Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
  9. 9Department of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  10. 10Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  11. 11Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  12. 12Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  13. 13Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  14. 14Department of Pathology, Medical University of Vienna, Vienna, Austria.
  15. 15Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  16. 16Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
  17. 17Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
  18. 18Center for Pathophysiology of Toulouse Purpan, INSERM UMR1043, CNRS UMR5282, Paul Sabatier University, Toulouse, France.
  19. 19Institute of Science and Technology Austria, Klosterneuburg, Austria.
  20. 20Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  1. §Corresponding author. Email: kaan.boztug{at}ccri.at
  • * These authors contributed equally to this work.

  • These authors contributed equally to this work.

  • Deceased.

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