FocusTUMOR IMMUNOLOGY

Shed it, and help—LAG3 cleavage drives conventional CD4+ T cells to overcome resistance to PD-1 immunotherapy

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Science Immunology  17 Jul 2020:
Vol. 5, Issue 49, eabc8644
DOI: 10.1126/sciimmunol.abc8644

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Abstract

LAG3 cleavage from conventional CD4+ T cells, but not CD8+ T cells, is required for effective PD-1 blockade.

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