Research ArticleIMMUNODEFICIENCY

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

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Science Immunology  24 Jul 2020:
Vol. 5, Issue 49, eabc9492
DOI: 10.1126/sciimmunol.abc9492

Article Information

vol. 5 no. 49

PubMed: 
Published By: 
History: 
  • Received May 22, 2020
  • Accepted June 11, 2020
  • .

Author Information

  1. Lauren J. Howson1,*,
  2. Wael Awad1,2,
  3. Anouk von Borstel1,
  4. Hui Jing Lim3,
  5. Hamish E. G. McWilliam3,4,
  6. Maria L. Sandoval-Romero1,
  7. Shamik Majumdar5,
  8. Abdul Rezzak Hamzeh6,7,
  9. Thomas D. Andrews6,7,
  10. David H. McDermott5,
  11. Philip M. Murphy5,
  12. Jérôme Le Nours1,2,
  13. Jeffrey Y. W. Mak8,9,
  14. Ligong Liu8,9,
  15. David P. Fairlie8,9,
  16. James McCluskey3,
  17. Jose A. Villadangos3,4,
  18. Matthew C. Cook6,7,
  19. Stephen J. Turner10,
  20. Martin S. Davey1,,
  21. Samar Ojaimi11,12,13, and
  22. Jamie Rossjohn1,2,14,*
  1. 1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  2. 2Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
  3. 3Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.
  4. 4Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.
  5. 5Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  6. 6Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Acton, Australian Capital Territory, Australia.
  7. 7Department of Immunology, Canberra Hospital, Canberra, Australian Capital Territory, Australia.
  8. 8Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  9. 9ARC Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland, Australia.
  10. 10Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  11. 11Department of Infectious Diseases, Monash Health, Clayton, Victoria, Australia.
  12. 12Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia.
  13. 13Department of Allergy and Immunology, Monash Health, Clayton, Victoria, Australia.
  14. 14Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
  1. *Corresponding author. Email: jamie.rossjohn{at}monash.edu (J.R.); lauren.howson{at}monash.edu (L.J.H.)
  • These authors contributed equally to this work.

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