Comprehensive mapping of immune perturbations associated with severe COVID-19

Leticia Kuri-Cervantes; M. Betina Pampena; Wenzhao Meng; Aaron M. Rosenfeld; Caroline A.G. Ittner; Ariel R. Weisman; Roseline S. Agyekum; Divij Mathew; Amy E. Baxter; Laura A. Vella; Oliva Kuthuru; Sokratis A. Apostolidis; Luanne Bershaw; Jeanette Dougherty; Allison R. Greenplate; Ajinkya Pattekar; Justin Kim; Nicholas Han; Sigrid Gouma; Madison E. Weirick; Claudia P. Arevalo; Marcus J. Bolton; Eileen C. Goodwin; Elizabeth M. Anderson; Scott E. Hensley; Tiffanie K. Jones; Nilam S. Mangalmurti; Eline T. Luning Prak; E. John Wherry; Nuala J. Meyer; Michael R. Betts

doi:10.1126/sciimmunol.abd7114

Research ArticleCORONAVIRUS

Comprehensive mapping of immune perturbations associated with severe COVID-19

View ORCID ProfileLeticia Kuri-Cervantes¹,²,^†,
View ORCID ProfileM. Betina Pampena¹,²,^†,
Wenzhao Meng³,
Aaron M. Rosenfeld³,
Caroline A.G. Ittner⁴,
View ORCID ProfileAriel R. Weisman⁴,
View ORCID ProfileRoseline S. Agyekum⁴,
View ORCID ProfileDivij Mathew ¹,⁵,
View ORCID ProfileAmy E. Baxter¹,⁵,
View ORCID ProfileLaura A. Vella ²,⁶,
View ORCID ProfileOliva Kuthuru²,⁵,
View ORCID ProfileSokratis A. Apostolidis²,⁵,⁷,
View ORCID ProfileLuanne Bershaw²,⁵,
View ORCID ProfileJeanette Dougherty²,⁵,
View ORCID ProfileAllison R. Greenplate²,⁵,
View ORCID ProfileAjinkya Pattekar²,⁸,
View ORCID ProfileJustin Kim²,⁵,
View ORCID ProfileNicholas Han²,⁵,
Sigrid Gouma¹,²,
View ORCID ProfileMadison E. Weirick¹,²,
View ORCID ProfileClaudia P. Arevalo¹,²,
View ORCID ProfileMarcus J. Bolton¹,²,
Eileen C. Goodwin¹,²,
View ORCID ProfileElizabeth M. Anderson¹,²,
View ORCID ProfileScott E. Hensley¹,²,
View ORCID ProfileTiffanie K. Jones⁴,
View ORCID ProfileNilam S. Mangalmurti²,⁴,
View ORCID ProfileEline T. Luning Prak ³,
View ORCID ProfileE. John Wherry *,²,⁵,⁹,
View ORCID ProfileNuala J. Meyer *,⁴ and
View ORCID ProfileMichael R. Betts*,¹,²

¹Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
²Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
³Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA.
⁴Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁵Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁶Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA.
⁷Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.
⁸Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.
⁹Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.

↵*Correspondence to:

betts{at}pennmedicine.upenn.edu; nuala.meyer{at}pennmedicine.upenn.edu; wherry{at}pennmedicine.upenn.edu

↵† These authors contributed equally.

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Science Immunology 15 Jul 2020:
Vol. 5, Issue 49, eabd7114
DOI: 10.1126/sciimmunol.abd7114

Leticia Kuri-Cervantes

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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M. Betina Pampena

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Wenzhao Meng

3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA.

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Aaron M. Rosenfeld

3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA.

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Caroline A.G. Ittner

4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Ariel R. Weisman

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Roseline S. Agyekum

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Divij Mathew

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Amy E. Baxter

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Laura A. Vella

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

6Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA.

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Oliva Kuthuru

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Sokratis A. Apostolidis

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

7Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.

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Luanne Bershaw

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Jeanette Dougherty

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Allison R. Greenplate

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Ajinkya Pattekar

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

8Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.

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Justin Kim

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Nicholas Han

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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Sigrid Gouma

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Madison E. Weirick

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Claudia P. Arevalo

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Marcus J. Bolton

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Eileen C. Goodwin

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Elizabeth M. Anderson

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Scott E. Hensley

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Tiffanie K. Jones

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Nilam S. Mangalmurti

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Eline T. Luning Prak

3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA.

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E. John Wherry

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

9Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.

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For correspondence: betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu

Nuala J. Meyer

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For correspondence: betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu

Michael R. Betts

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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For correspondence: betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu

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Comprehensive mapping of immune perturbations associated with severe COVID-19

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