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Research ArticleCORONAVIRUS
Comprehensive mapping of immune perturbations associated with severe COVID-19
- View ORCID ProfileLeticia Kuri-Cervantes1,2,*,
- View ORCID ProfileMaria Betina Pampena1,2,*,
- Wenzhao Meng3,
- Aaron M. Rosenfeld3,
- Caroline A. G. Ittner4,
- View ORCID ProfileAriel R. Weisman4,
- View ORCID ProfileRoseline S. Agyekum4,
- View ORCID ProfileDivij Mathew1,5,
- View ORCID ProfileAmy E. Baxter1,5,
- View ORCID ProfileLaura A. Vella2,6,
- View ORCID ProfileOliva Kuthuru2,5,
- View ORCID ProfileSokratis A. Apostolidis2,5,7,
- View ORCID ProfileLuanne Bershaw2,5,
- View ORCID ProfileJeanette Dougherty2,5,
- View ORCID ProfileAllison R. Greenplate2,5,
- View ORCID ProfileAjinkya Pattekar2,8,
- View ORCID ProfileJustin Kim2,5,
- View ORCID ProfileNicholas Han2,5,
- View ORCID ProfileSigrid Gouma1,2,
- View ORCID ProfileMadison E. Weirick1,2,
- View ORCID ProfileClaudia P. Arevalo1,2,
- View ORCID ProfileMarcus J. Bolton1,2,
- Eileen C. Goodwin1,2,
- View ORCID ProfileElizabeth M. Anderson1,2,
- View ORCID ProfileScott E. Hensley1,2,
- View ORCID ProfileTiffanie K. Jones4,
- View ORCID ProfileNilam S. Mangalmurti2,4,
- View ORCID ProfileEline T. Luning Prak3,
- View ORCID ProfileE. John Wherry2,5,9,†,
- View ORCID ProfileNuala J. Meyer4,† and
- View ORCID ProfileMichael R. Betts1,2,†
- 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA.
- 4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 6Division of Infectious Diseases, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 7Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 8Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 9Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- ↵†Corresponding author. Email: betts{at}pennmedicine.upenn.edu (M.R.B.); nuala.meyer{at}pennmedicine.upenn.edu (N.J.M.); wherry{at}pennmedicine.upenn.edu (E.J.W.)
↵* These authors contributed equally to this work.
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Science Immunology 15 Jul 2020:
Vol. 5, Issue 49, eabd7114
DOI: 10.1126/sciimmunol.abd7114
Vol. 5, Issue 49, eabd7114
DOI: 10.1126/sciimmunol.abd7114
Leticia Kuri-Cervantes
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maria Betina Pampena
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wenzhao Meng
3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Aaron M. Rosenfeld
3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Caroline A. G. Ittner
4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ariel R. Weisman
4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Roseline S. Agyekum
4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Divij Mathew
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Amy E. Baxter
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Laura A. Vella
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
6Division of Infectious Diseases, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Oliva Kuthuru
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sokratis A. Apostolidis
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
7Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Luanne Bershaw
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jeanette Dougherty
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Allison R. Greenplate
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ajinkya Pattekar
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
8Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Justin Kim
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nicholas Han
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sigrid Gouma
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Madison E. Weirick
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Claudia P. Arevalo
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Marcus J. Bolton
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eileen C. Goodwin
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Elizabeth M. Anderson
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Scott E. Hensley
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tiffanie K. Jones
4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nilam S. Mangalmurti
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eline T. Luning Prak
3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA.
E. John Wherry
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
5Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
9Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Nuala J. Meyer
4Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael R. Betts
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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