Contents
August 2020
Vol 5, Issue 50
Vol 5, Issue 50
Focus
- Resident TH17 cells “break bad” in kidney autoimmunity
Resident memory TH17 cells (TRM17 cells) are induced by microbial infections in kidneys and amplify renal autoimmunity.
Research Articles
- Natural killer cell immunotypes related to COVID-19 disease severity
The NK cell activation landscape in acute SARS-CoV-2 infection is associated with COVID-19 disease severity.
- Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration
Activation of the TRPA1 nociceptor in mammalian skin promotes local and distant tissue regeneration and reduces scar formation.
- Targeting Piezo1 unleashes innate immunity against cancer and infectious disease
Blockade of the Piezo1 mechanoreceptor decreases myeloid cell suppression of immune responses to cancer and polymicrobial sepsis.
- HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses
Herpes simplex virus glycoprotein D allows viral evasion of protective host ADCC responses by interfering with LIGHT-HVEM signaling.
- Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease
CD4+ TRM17 cells become activated by inflammatory cytokines to produce IL-17A and thereby promote autoimmunity.
- Functional heterogeneity of alveolar macrophage population based on expression of CXCL2
Pulmonary fungal infections generate heterogenous alveolar macrophage subpopulations.
Research Resource
- Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Single-cell sequencing analyses reveal changes in B and T cell transcriptional states in the context of ulcerative colitis.
Report
- An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
A CD25-dependent IL-2 mutein expanded regulatory T cells and controlled spontaneous diabetes in nonobese diabetic (NOD) mice.
Editors' Choice
- The (inner) world according to GARP: Genetic susceptibility and regulatory T cells
A human autoimmune and allergic disease susceptibility variant on chromosome 11 results in the reduced expression of the gene encoding the GARP protein and thus compromises the function of regulatory T cells.
About The Cover
ONLINE COVER Renal Memories of Past Infections. This month's cover is an immunofluorescence image of a thin section of mouse kidney that includes a single glomerulus consisting of a tuft of capillary endothelial cells stained for endomucin (green). The glomerular capillaries are separated from epithelial lining cells positive for synaptopodin (pink) by the glomerular basement membrane, the kidney structure that allows for filtering of the blood. Krebs et al. found that mice infected systemically with Staphylococcus aureus followed with antibiotic treatment to clear the infection maintained a stable population of kidney-resident memory T cells capable of producing IL-17A. These renal TRM17 cells could be reactivated during autoimmune kidney disease leading to exacerbated tissue damage. [CREDIT: CHRISTIAN KREBS/UKE HAMBURG]
