Research ArticleVACCINES

HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses

See allHide authors and affiliations

Science Immunology  14 Aug 2020:
Vol. 5, Issue 50, eaax2454
DOI: 10.1126/sciimmunol.aax2454

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Subversion of ADCC by herpes viruses

Antibodies to viruses produced after infection or vaccination can protect the host by virus neutralization or through antibody-dependent cellular cytotoxicity (ADCC). The strong ADCC response elicited by an HSV-2 vaccine strain lacking glycoprotein D (∆gD-2) provides robust protection against wild-type HSV-2 challenge in mice. Burn Aschner et al. tested the hypothesis that HSV-2 gD binding to the HVEM entry receptor interferes with host immunity by blocking an HVEM-dependent signaling pathway needed to achieve a protective ADCC response. They found that the ∆gD-2 vaccine–induced ADCC response in mice requires HVEM and its ligand LIGHT during the inductive phase and HVEM and the FcγIV receptor during the effector phase. This research provides a deeper understanding of the host signaling pathways that support the establishment of ADCC.

View Full Text

Stay Connected to Science Immunology