Research ArticleAUTOIMMUNITY

Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease

See allHide authors and affiliations

Science Immunology  07 Aug 2020:
Vol. 5, Issue 50, eaba4163
DOI: 10.1126/sciimmunol.aba4163

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Autoimmunity promoter

Tissue-resident memory T (TRM) cells are involved in peripheral immunity against reinfection, but their role in autoimmunity is unclear. Krebs et al. examine the contribution of TRM cells in patients with antineutrophil cytoplasmic antibody (ANCA)–dependent glomerulonephritis (GN). They identified multiple T cell subsets in healthy kidney tissue biopsies, but a marked increase in CD4+ TRM cells was seen in kidney biopsies from patients with ANCA-GN. They infected mice with Staphylococcus aureus, which induced renal TH17 cells that had a TRM cell phenotype and persisted in kidney tissue. In a mouse model of crescentic GN, S. aureus infection aggravated kidney pathology and appeared to drive localized renal autoimmune responses. These findings provide critical insight into the role of CD4+ TRM cells in contributing to autoimmune disease.

View Full Text

Stay Connected to Science Immunology