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An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice

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Science Immunology  14 Aug 2020:
Vol. 5, Issue 50, eaba5264
DOI: 10.1126/sciimmunol.aba5264

Article Information

vol. 5 no. 50

PubMed: 
Published By: 
History: 
  • Received December 11, 2019
  • Accepted July 17, 2020
  • .

Author Information

  1. Liliane Khoryati1,
  2. Minh Nguyet Pham1,
  3. McKenna Sherve1,
  4. Swarnima Kumari1,
  5. Kevin Cook2,
  6. Josh Pearson2,
  7. Marika Bogdani3,
  8. Daniel J. Campbell1,4,* and
  9. Marc A. Gavin1,*
  1. 1Immunology Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.
  2. 2Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA 94080, USA.
  3. 3Matrix Biology Program, Benaroya Research Institute, Seattle, WA 98101, USA.
  4. 4Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.
  1. *Corresponding author. Email: campbell{at}benaroyaresearch.org (D.J.C.); mgavin{at}omeros.com (M.A.G.)

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