Research ResourcesINFLAMMATORY BOWEL DISEASE

Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

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Science Immunology  21 Aug 2020:
Vol. 5, Issue 50, eabb4432
DOI: 10.1126/sciimmunol.abb4432

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Profiles of rogue gut lymphocytes

Dysregulated human gut B and T lymphocytes contribute to the immunopathogenesis of ulcerative colitis (UC), a type of inflammatory bowel disease (IBD) characterized by mucosal damage in the colon. Boland et al. probed the immunologic perturbations associated with active UC by sequencing mRNA and clonal antigen receptors from individual CD45+ cells isolated from rectal biopsies or blood of patients and healthy controls. The resulting single-cell sequencing resource revealed heterogeneity among tissue-resident memory T cells (TRM) in UC, including expansion of an inflammatory CD8+ TRM subset expressing the Eomesodermin transcription factor. The identification of this TRM population and other disease-associated T and B cell subsets provides a platform for future functional studies addressing how these subsets conspire to trigger chronic mucosal injury in UC.

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