Contents
September 2020
Vol 5, Issue 51
Vol 5, Issue 51
Focus
- Illuminating the core of adaptive immunity—how the regulatory genome controls Rag chromatin dynamics
E2A specifies adaptive immunity by instructing large-scale topological changes for Rag gene super-enhancer formation (see the related Research Article by Miyazaki et al.).
Research Articles
- Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
Longitudinal analysis of the immune response in patients with COVID-19 identifies a myeloid signature associated with severe disease.
- The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages
The type I interferon response after myocardial infarction induces a cytoprotective Nrf2-dependent program in cardiac macrophages.
- IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
High-affinity CD4 T cells produce IL-21 to help CD8 T cells differentiate into tissue-resident memory cells in the brain.
- Sympathetic nervous tone limits the development of myeloid-derived suppressor cells
Disruption of α-adrenergic signaling promotes development of myeloid-derived suppressor cells and regulates tumor immunity.
- Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells
Programming of lymph node fibroblastic reticular cells by type I interferons is needed for effective antiviral CD8+ T cell responses.
- The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells
Distinct enhancer modules drive expression of Rag genes during T and B cell development (see the related Focus by Wang and Rothenberg).
Research Resource
- Transcriptomic and clonal characterization of T cells in the human central nervous system
We have profiled cerebrospinal fluid T cells in healthy individuals and patients with MS using single-cell RNA and TCR sequencing.
Report
- MAIT cell activation and dynamics associated with COVID-19 disease severity
MAIT cell activation and decline in blood are associated with COVID-19 severity, features that dynamically recover in convalescence.
Review
- Immune surveillance of the liver by T cells
This review discusses hepatic T cell responses, which play a key role in infectious, inflammatory, and neoplastic liver diseases.
Erratum
Editors' Choice
- Keepin’ it regulatory: Foxp3 gets a BAFfling SWItch
A novel role for SWI/SNF complexes in tuning Foxp3 expression and activity in Tregs.
About The Cover
ONLINE COVER Sinusoidal Patrolling. This month's cover features a cutaway illustration of lymphocytes and erythrocytes traveling down a narrow liver sinusoid lined by fenestrated endothelial cells. A Review by Ficht and Iannacone summarizes current knowledge about the hepatic T cell subsets tasked with immune surveillance. Lymphocyte processes can extend through the small pores in the sinusoidal passages in search of stimulatory ligands displayed on hepatocytes. The T cell on the right is a cytotoxic CD8+ cell that is in the process of killing a hepatocyte displaying activating peptide-MHC ligands. [CREDIT: PAOLO MONTUSCHI/GRAFICA BIOMEDICA]
