September 2020
Vol 5, Issue 51

About The Cover

Cover image expansion

ONLINE COVER Sinusoidal Patrolling. This month's cover features a cutaway illustration of lymphocytes and erythrocytes traveling down a narrow liver sinusoid lined by fenestrated endothelial cells. A Review by Ficht and Iannacone summarizes current knowledge about the hepatic T cell subsets tasked with immune surveillance. Lymphocyte processes can extend through the small pores in the sinusoidal passages in search of stimulatory ligands displayed on hepatocytes. The T cell on the right is a cytotoxic CD8+ cell that is in the process of killing a hepatocyte displaying activating peptide-MHC ligands. [CREDIT: PAOLO MONTUSCHI/GRAFICA BIOMEDICA]