Research ArticleMYELOID CELLS

Sympathetic nervous tone limits the development of myeloid-derived suppressor cells

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Science Immunology  11 Sep 2020:
Vol. 5, Issue 51, eaay9368
DOI: 10.1126/sciimmunol.aay9368

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A sympathetic tumor response

The sympathetic nervous system (SNS) has been shown to regulate immune responses through various mechanisms. Nevin et al. now show that ablation of SNS signaling can suppress tumor immunity, and this is caused by disruption in α-adrenergic signaling that is needed for myeloid cell maturation. In tumor-bearing mice, this disruption promotes the accumulation of immature myeloid-derived suppressor cells, which allows for tumor growth. In the absence of intact SNS signaling, MDSCs also promote expansion of regulatory T cells by secreting the alarmin heterodimer S100A8/A9. These results provide insight into the contributions of SNS signaling in innate and adaptive immunity, particularly in the context of tumor immunity.

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