The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

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Science Immunology  04 Sep 2020:
Vol. 5, Issue 51, eabb1455
DOI: 10.1126/sciimmunol.abb1455

To each their own

Recombination activating genes (RAGs) RAG1 and RAG2 play central roles in assembling functional T and B cell receptors in developing lymphocytes. Expression of Rag1 and Rag2 in hematopoiesis is restricted to these two lymphoid lineages, but precisely how this is accomplished has remained a mystery. Here, Miyazaki et al. have identified three key enhancer elements that recruit the transcription factor E2A to promote the expression of Rag1 and Rag2 genes during lymphocyte development. By generating mouse strains lacking one or more of these enhancer elements, they report that T and B cells use distinct enhancer modules to activate and maintain expression of Rag1 and Rag2 genes.

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