Research ArticleDEVELOPMENTAL IMMUNOLOGY

The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

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Science Immunology  04 Sep 2020:
Vol. 5, Issue 51, eabb1455
DOI: 10.1126/sciimmunol.abb1455

Article Information

vol. 5 no. 51

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Published By: 
History: 
  • Received February 9, 2020
  • Accepted July 21, 2020
  • .

Author Information

  1. Kazuko Miyazaki1,*,
  2. Hitomi Watanabe2,*,
  3. Genki Yoshikawa3,
  4. Kenian Chen4,
  5. Reiko Hidaka1,
  6. Yuki Aitani1,
  7. Kai Osawa1,
  8. Rie Takeda2,
  9. Yotaro Ochi5,
  10. Shizue Tani-ichi6,
  11. Takuya Uehata7,
  12. Osamu Takeuchi7,
  13. Koichi Ikuta6,
  14. Seishi Ogawa5,8,9,
  15. Gen Kondoh2,
  16. Yin C. Lin4,
  17. Hiroyuki Ogata3 and
  18. Masaki Miyazaki1,
  1. 1Laboratory of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  2. 2Laboratory of Integrative Biological Sciences, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  3. 3Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.
  4. 4Baylor Institute for Immunology Research, Baylor Scott & White Research Institute, Dallas, TX, USA.
  5. 5Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
  6. 6Laboratory of Immune Regulation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  7. 7Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
  8. 8Institute for the Advanced Study of Human Biology (WPI ASHBi), Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
  9. 9Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
  1. Corresponding author. Email: mmiyazaki{at}infront.kyoto-u.ac.jp
  • * These authors contributed equally to this work.

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