Research ArticleANTIVIRAL IMMUNITY

Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells

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Science Immunology  11 Sep 2020:
Vol. 5, Issue 51, eabb7066
DOI: 10.1126/sciimmunol.abb7066

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Stromal cells poised to defend

Fibroblastic reticular cells (FRCs) in lymph nodes help establish niches where productive cell interactions can engender effective immune defense. Perez-Shibayama et al. evaluated the contribution of type I interferons and interferon-stimulated genes to supporting normal FRC function by studying mice with conditional deletion of the type I interferon receptor (Ifnar) in FRCs. Single-cell RNA sequencing of Ifnar-deficient FRCs revealed baseline perturbations in FRC differentiation associated with changes in myeloid cell composition. Mice with Ifnar-deficient FRCs were compromised in their ability to control spread of a localized virus infection due, in part, to impaired CD8+ T cells displaying features of exhaustive activation. Sensing of type I interferons by FRCs is critical to maintaining secondary lymphoid tissues in a poised state ready to repel viral infections.

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