Research ResourcesNEUROIMMUNOLOGY

Transcriptomic and clonal characterization of T cells in the human central nervous system

See allHide authors and affiliations

Science Immunology  18 Sep 2020:
Vol. 5, Issue 51, eabb8786
DOI: 10.1126/sciimmunol.abb8786

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Cerebrospinal fluid snapshot

The central nervous system (CNS) features mechanisms to protect against untoward inflammation yet allowing immune surveillance for pathogens. Pappalardo et al. profiled T cells in the cerebrospinal fluid (CSF) of healthy individuals and patients with multiple sclerosis (MS) using single-cell RNA and TCR sequences to define CNS immune homeostasis in both healthy donors and patients with MS. In healthy individuals, clonally expanded CSF T cells are largely distinct from those found in the blood with effector, IFNγ, and tissue adaptation signatures, whereas CSF T cells from patients with MS differ from healthy controls with a gene expression signature consistent with elevated activation and cytotoxicity. These findings provide insight into the unique immune environment in the CSF under normal and disease-associated conditions.

View Full Text

Stay Connected to Science Immunology