Research ArticleCORONAVIRUS

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

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Science Immunology  17 Sep 2020:
Vol. 5, Issue 51, eabd6197
DOI: 10.1126/sciimmunol.abd6197

Article Information

vol. 5 no. 51

PubMed: 
Published By: 
History: 
  • Received July 2, 2020
  • Revision received August 11, 2020
  • Accepted September 14, 2020
  • .

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Author Information

  1. Elizabeth R. Mann1,2,*,
  2. Madhvi Menon1,*,
  3. Sean Blandin Knight1,3,*,
  4. Joanne E. Konkel1,*,
  5. Christopher Jagger1,
  6. Tovah N. Shaw1,
  7. Siddharth Krishnan1,
  8. Magnus Rattray4,
  9. Andrew Ustianowski5,
  10. Nawar Diar Bakerly3,
  11. Paul Dark6,7,
  12. Graham M. Lord1,
  13. Angela Simpson6,
  14. Timothy Felton6,
  15. Ling-Pei Ho8,
  16. NIHR Respiratory TRC,
  17. Marc Feldmann9,
  18. CIRCO,
  19. John R. Grainger1,§ and
  20. Tracy Hussell1,*,§
  1. 1Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester M13 9PL, UK.
  2. 2Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 5th Floor St. Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK.
  3. 3Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
  4. 4Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
  5. 5Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK.
  6. 6Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, UK.
  7. 7Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
  8. 8MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  9. 9Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford OX3 7LD, UK.
  1. §Corresponding author. Email: john.grainger-2{at}manchester.ac.uk (J.R.G.); tracy.hussell{at}manchester.ac.uk (T.H.)
  • * These authors contributed equally to this work.

  • The members of the NIHR Respiratory Translational Research Collaboration (TRC) collaborative group are listed at the end of the Acknowledgments.

  • The members of the Coronavirus Immune Response and Clinical Outcomes (CIRCO) collaborative group can be found at the end of the Acknowledgments.

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