MAIT cell activation and dynamics associated with COVID-19 disease severity

Tiphaine Parrot; Jean-Baptiste Gorin; Andrea Ponzetta; Kimia T. Maleki; Tobias Kammann; Johanna Emgård; André Perez-Potti; Takuya Sekine; Olga Rivera-Ballesteros; The Karolinska COVID-19 Study Group; Sara Gredmark-Russ; Olav Rooyackers; Elin Folkesson; Lars I. Eriksson; Anna Norrby-Teglund; Hans-Gustaf Ljunggren; Niklas K. Björkström; Soo Aleman; Marcus Buggert; Jonas Klingström; Kristoffer Strålin; Johan K. Sandberg

doi:10.1126/sciimmunol.abe1670

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MAIT cell activation and dynamics associated with COVID-19 disease severity

View ORCID ProfileTiphaine Parrot¹,*,
View ORCID ProfileJean-Baptiste Gorin¹,*,
View ORCID ProfileAndrea Ponzetta¹,
View ORCID ProfileKimia T. Maleki¹,
View ORCID ProfileTobias Kammann¹,
Johanna Emgård¹,
View ORCID ProfileAndré Perez-Potti¹,
View ORCID ProfileTakuya Sekine¹,
View ORCID ProfileOlga Rivera-Ballesteros¹,
The Karolinska COVID-19 Study Group†,
Sara Gredmark-Russ¹,²,
Olav Rooyackers³,⁴,
Elin Folkesson²,⁵,
Lars I. Eriksson ⁴,⁶,
Anna Norrby-Teglund¹,
Hans-Gustaf Ljunggren ¹,
Niklas K. Björkström¹,
Soo Aleman²,⁷,
Marcus Buggert¹,
Jonas Klingström¹,
Kristoffer Strålin ²,⁷ and
Johan K. Sandberg ¹,‡

¹Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
²Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
³Department of Clinical Science, Interventions and Technology, Karolinska Institutet, Stockholm, Sweden.
⁴Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
⁵Division of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
⁶Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
⁷Division of Infectious Diseases and Dermatology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

↵‡Corresponding author. Email: johan.sandberg{at}ki.se

↵* These authors contributed equally to this work.
↵† The Karolinska COVID-19 Study Group members are listed at the end of the Acknowledgments.

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Science Immunology 25 Sep 2020:
Vol. 5, Issue 51, eabe1670
DOI: 10.1126/sciimmunol.abe1670

Tiphaine Parrot

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Jean-Baptiste Gorin

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Andrea Ponzetta

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Kimia T. Maleki

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Tobias Kammann

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Johanna Emgård

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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André Perez-Potti

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Takuya Sekine

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Olga Rivera-Ballesteros

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Sara Gredmark-Russ

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

2Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.

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Olav Rooyackers

3Department of Clinical Science, Interventions and Technology, Karolinska Institutet, Stockholm, Sweden.

4Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.

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Elin Folkesson

2Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.

5Division of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

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Lars I. Eriksson

4Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.

6Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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Anna Norrby-Teglund

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Hans-Gustaf Ljunggren

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Niklas K. Björkström

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Soo Aleman

2Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.

7Division of Infectious Diseases and Dermatology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

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Marcus Buggert

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Jonas Klingström

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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Kristoffer Strålin

2Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.

7Division of Infectious Diseases and Dermatology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

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Johan K. Sandberg

1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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ORCID record for Johan K. Sandberg
For correspondence: johan.sandberg@ki.se

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MAIT cell activation and dynamics associated with COVID-19 disease severity

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