Research ArticleMUCOSAL IMMUNITY

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

See allHide authors and affiliations

Science Immunology  09 Oct 2020:
Vol. 5, Issue 52, eabb5439
DOI: 10.1126/sciimmunol.abb5439

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

A nose for inflammation

The nasal-associated lymphoid tissues (NALTs) are lymphoid organs in the nasal mucosa that are sites of inhaled antigen deposition. Here, Bedford et al. study induction of immunity in NALTs and identify a role for conventional dendritic cells (cDCs) in suppressing T cell responses during the steady state. Similar cDCs are found in human NALTs in adenoids and tonsils and can also inhibit T cell responses and prevent immune activation. Inflammation induced in nasal mucosa by viral infection induces local recruitment of monocyte-derived DCs, which overrides the effects of cDCs and allows for T cell priming. These results provide mechanistic insight into steady state and inflammatory responses in NALTs.

View Full Text

Stay Connected to Science Immunology