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A nose for inflammation
The nasal-associated lymphoid tissues (NALTs) are lymphoid organs in the nasal mucosa that are sites of inhaled antigen deposition. Here, Bedford et al. study induction of immunity in NALTs and identify a role for conventional dendritic cells (cDCs) in suppressing T cell responses during the steady state. Similar cDCs are found in human NALTs in adenoids and tonsils and can also inhibit T cell responses and prevent immune activation. Inflammation induced in nasal mucosa by viral infection induces local recruitment of monocyte-derived DCs, which overrides the effects of cDCs and allows for T cell priming. These results provide mechanistic insight into steady state and inflammatory responses in NALTs.
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