Research ArticleLUNG DISEASE

Itaconate controls the severity of pulmonary fibrosis

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Science Immunology  23 Oct 2020:
Vol. 5, Issue 52, eabc1884
DOI: 10.1126/sciimmunol.abc1884

Article Information

vol. 5 no. 52

Published By: 
  • Received April 10, 2020
  • Accepted September 29, 2020
  • .

Author Information

  1. Patricia P. Ogger1,
  2. Gesa J. Albers1,2,
  3. Richard J. Hewitt1,3,
  4. Brendan J. O’Sullivan4,5,
  5. Joseph E. Powell6,7,
  6. Emily Calamita1,
  7. Poonam Ghai1,
  8. Simone A. Walker1,
  9. Peter McErlean1,
  10. Peter Saunders3,
  11. Shaun Kingston3,
  12. Philip L. Molyneaux1,3,
  13. John M. Halket8,
  14. Robert Gray8,
  15. Daniel C. Chambers4,5,
  16. Toby M. Maher1,3,9,
  17. Clare M. Lloyd1,2 and
  18. Adam J. Byrne1,2,*
  1. 1National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
  2. 2Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
  3. 3Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
  4. 4Queensland Lung Transplant Service, Prince Charles Hospital, Brisbane, Queensland, Australia.
  5. 5Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  6. 6Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia.
  7. 7Cellular Genomics Futures Institute, University of New South Wales, Kensington, Sydney, Australia.
  8. 8Mass Spectrometry Facility King’s College London, London SE1 9NH, UK.
  9. 9Hastings Centre for Pulmonary Research and Division of Pulmonary, Critical Care and Sleep Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  1. *Corresponding author. Email: a.byrne{at}


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